OVERVIEW

22nd Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy is organized by the European School of Haematology (ESH). This Online CME Course commences from Oct 01 - 04, 2020.

What are the objectives of the 22nd Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy?

Course Objectives:
Upon completion of this CME activity, participants should be able to:
• Understand current and new concepts of the signal transduction pathways involved in chronic myeloid leukemia (CML) and the mechanisms of action of tyrosine kinase inhibitors and other new agents.
• Have insight into the possible mechanisms of genomic instability that predispose to the formation of the BCR-ABL fusion gene and predispose also to disease progression and the consequences of such instability.
• Define a leukemia stem cell and its relationship to disease kinetics in so far as current knowledge permits.
• Evaluate the merits of various management decisions, e.g. how to start treatment for patients in the different phases of CML, how to assess success or failure of initial treatment, what approaches to consider for patients who have failed to respond well to initial treatment, including assessing the precise role of second and third-generation TKIs and other non-molecular therapeutic approaches.
• Review the current recommendations and discuss current concepts and challenges of monitoring individual patients with hematologic, cytogenetic, and molecular (RQ-PCR) methods.
• Assess the role of allogeneic stem cell transplantation in the management of CML.
• Critically evaluate the possible role of the different immunotherapeutic approaches in the treatment of CML.
• Discuss current data and ongoing research regarding treatment-free survival as an endpoint in CML management.
• Discuss patient-reported outcomes and their role in the management of patients with CML.