Curious Clinicians - The Forgotten Factor (2026)
Podcast
0.75 AMA PRA Category 1 Credit™ ...Faculty
OVERVIEW
Curious Clinicians - The Forgotten Factor (2026) is organized by VCU Health Continuing Education.
Date:
Thursday, January 15, 2026, 3:30 PM - Thursday, December 31, 2026, 11:59 PM
Description:
Why doesn’t factor 12 deficiency cause bleeding?
In July 1953, freight brakeman John Hageman’s doctors faced a scenario that might feel familiar to anyone who has ever done preoperative medicine consults. Hageman had planned to undergo a partial gastrectomy for peptic ulcer disease, but his preoperative tests showed a prolonged clotting time. In the 1950s, we knew about other diseases with prolonged clotting times; hemophilia in particular, which at the time referred to what we now know as hemophilia A (Factor 8 deficiency) and hemophilia B (then known as Christmas disease and now known as Factor 9 deficiency). But Oscar Ratnoff and Joan Colopy, two scientists who investigated the case further, found a few things that made it clear Hageman didn’t have either condition. So why did he have a prolonged clotting time without any bleeding symptoms?
Objectives:
Upon completion of this activity, you will be able to:
- Describe the pathophysiology of Factor 12 deficiency.
- Explain why Factor 12 deficiency does not result in a bleeding tendency.
- Describe how Factor 12 deficiency led to understanding of the modern coagulation cascade.
ACCREDITATION & CREDITS
Accreditation:
In support of improving patient care, this activity has been planned and implemented by Curious Clinicians and VCU Health Continuing Education. VCU Health Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
VCU Health Continuing Education designates this enduring material activity for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
It is the responsibility of the participant to provide the correct information [ABIM ID Number and DOB (in MMDD format)] in order to receive MOC credit for participating in a CE activity.
Credits:
AMA PRA Category 1 Credits™ (0.75 hours), ABIM MOC Part 2 (0.75 hours), Non-Physician Attendance (0.75 hours)
TARGET AUDIENCE
PhysicianPhysician AssistantCliniciansSPECIALITIES
HematologyMedical Genetics and Genomics
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