GIIDS - GI Inflammatory Diseases Summit

Across 3 days of in-depth discussion, share perspectives with industry leaders and overcome translational drug development challenges including: clinical trial design in a hyper-competitive landscape, targeting alternative proinflammatory pathways, and the potential of emerging antigen-specific and bio-therapeutics.

 

Be part of this inaugural summit to collaborate and gain the knowledge you need to confidently navigate the next 12 months of your anti-inflammatory and IBD research.

Attend this focused, discussion orientated forum to:
• Hear case-studies showcasing the safety and efficacy of antigen-specific, microbiome based, anti-inflammatory and small molecule candidates to better align your own research with the pace and direction of the rest of the field
• Understand the latest advancements in molecular profiling, precision medicine and pharmacodynamic biomarkers to better demonstrate efficacy in the clinic
• Equip yourself with strategies to optimize clinical trial success in a hypercompetitive patient recruitment landscape to more efficiently translate success through the clinic

Regulation of Colon Inflammation by Regulatory T-Cells, Microbiota & Bile Acid Metabolism 
Description: Bacterial metabolism of bile acids is mechanistically linked to genotoxic and inflammatory process that predispose to IBD and colorectal cancer (CRC). Bile acid metabolizing bacteria are also responsible for the extrathymic generation of regulatory T-cells, the rate limiting factors in the control of colon inflammation. Deregulation of inflammation involves epigenetic and gene expression changes that take place in gut infiltrating regulating T-cells. Understanding the interface of gut microbiota and Treg function in the gut will critically help in designing effective preventive and therapeutic strategies.

Join these experts as they present in detail on:
• Treg diversity and function in colon cancer
• Molecular pathways that regulate Treg functions and Treg/Th17 balance
• Microbial sulfur metabolism and colorectal cancer risk
• Genetics of bile acid metabolism and colorectal cancer risk

Main Conference - Jun 24 - 25, 2019