Cellular Plasticity: Reprogramming, Regeneration and Metaplasia (J3)

Cellular Plasticity: Reprogramming, Regeneration and Metaplasia (J3) is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Jan 27 - 31, 2019 at Keystone Resort, Keystone, Colorado, United States of America.

Course Description :
Traditionally, differentiated cells were thought to be post-mitotic. However, now we know mature cells in diverse tissues can reprogram, re-enter the cell cycle, and spawn other lineages (e.g., they revert back to stem cells or adopt other identities). The scientific and health implications are substantial. For one, cellular plasticity might be harnessed to regenerate damaged tissue (e.g., insulin-secreting cells, liver, gut), but repeated reprogramming events – as cells respond to inflammation/injury – can also cause tissue derangement (metaplasia) that predisposes to cancer. Furthermore, cancer cells can harness such plasticity mechanisms to subvert therapy. Thus, defining the mechanisms that allow mature cells to switch identities holds great promise for understanding disease pathogenesis and developing new therapies. This conference gathers the diverse, dynamic field of plasticity/reprogramming together for the first time with the aim of understanding if similar mechanisms underlie plasticity in diverse organs and organisms. The hypothesis is that cellular reprogramming occurs via evolutionarily conserved cellular processes as fundamental to a multicellular organism as apoptosis. Specifically, the conference aims to:
• Elucidate mechanisms of plasticity in diverse adult tissues
• Explore plasticity’s evolutionary context
• Elucidate its role in metaplasia/cancer, and
• Investigate how it can be harnessed therapeutically.

Plenary Session Topics :
• Plasticity and Signaling in Development and Homeostasis (Joint)
• Stem Cell Recruitment and Metaplasia
• Cancer and Plasticity
• Reprogramming Cells to Assemble and Repair Organs
• Plasticity and Signaling in Regeneration and Tumorigenesis (Joint)
• Workshop – Nomenclature in Cell Plasticity: “Plasticity,” “Dedifferentiation,” “Transdifferentiation,” “Reprogramming,” “Reversion” - Can We Agree What These Mean?
• Transcriptional Regulation of Cell Plasticity
• Injury, Inflammation and Regeneration
• Applications of Cell Plasticity

Additional details will be posted as soon as they are available.