Nathan D. Peffley MD

Nathan D. Peffley, M.D., is a board-certified anesthesiologist and critical care specialist at Mayo Clinic in Rochester, Minnesota. He serves as an Assistant Professor of Anesthesiology at the Mayo Clinic College of Medicine and Science, where he provides advanced perioperative and intensive care for patients with complex medical and surgical conditions. His clinical interests include anesthesiology, critical care medicine, extracorporeal membrane oxygenation (ECMO), perioperative management, and cardiothoracic critical care.

Dr. Peffley earned a Bachelor of Science in Finance from Miami University before receiving his Doctor of Medicine (M.D.) from The University of Toledo College of Medicine. He completed his residency in Anesthesiology and a fellowship in Anesthesiology Critical Care at the University of Michigan Health System. He is board certified by the American Board of Anesthesiology in both Anesthesiology and Critical Care Medicine.

At Mayo Clinic, Dr. Peffley specializes in the perioperative care of critically ill patients, with expertise in critical care anesthesiology, advanced hemodynamic management, and extracorporeal life support. He is actively involved in the care of patients requiring ECMO and other advanced life-support therapies, emphasizing evidence-based approaches to improve outcomes in critically ill adults.

In addition to his clinical practice, Dr. Peffley is committed to medical education and departmental quality improvement. He serves on Mayo Clinic's Clinical Competency Committee and Morbidity and Mortality Review Committee and has participated in Grand Rounds planning. He is an active member of several professional organizations, including the American Society of Anesthesiologists, the Society of Critical Care Medicine, the International Anesthesia Research Society, and the Society of Anesthesia and Sleep Medicine.

Dr. Peffley has authored peer-reviewed publications on extracorporeal membrane oxygenation, perioperative coagulation management, cardiothoracic anesthesiology, mechanical circulatory support, and intraoperative ventilatory strategies. His research focuses on advancing the care of critically ill surgical patients through innovations in critical care and perioperative medicine.