Masahiro Sakagami PhD

Dr. Sakagami's research focuses on pulmonary biopharmaceutics. Despite the potential advantages of respiratory drug delivery as a route of administration, our knowledge associated with pulmonary biopharmaceutics and pharmacology is still limited. Our group has developed and employed several in vivo and in vitro lung systems to characterize pulmonary disposition (absorption, metabolism, and clearance) of solutes and fluid, and to assess the therapeutic potential of new molecular entities for inhalation. Currently, the research is focused on corticosteroids, therapeutic macromolecular peptides, proteins and antibodies for inhalation in the treatment of asthma, emphysema and certain systemic diseases. These studies will provide valuable information on understanding pulmonary biopharmaceutics and pharmacology for inhaled therapeutics.