Lia Palomba, MD is an oncologist with extensive laboratory and clinical training. She has a strong interest in the biology of hematological malignancies and in novel approaches to immune therapy of lymphoma. Over the past several years she has developed a xenogeneic CD20 vaccine and showed that vaccination with a truncated, xenogeneic DNA CD20 vaccine can overcome tolerance towards the autoantigen CD20 and protect mice from a tumor challenge. A phase I CD20 vaccine clinical trial is actively accruing patients with refractory or recurrent B cell lymphoma at MSKCC and an identical study was completed incompanion animals.
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