James H. Flory MD, MSCE

James Flory MD, MSCE is an Assistant Professor in the Department of Health Policy and Research at Weill Cornell Medical College, and an Assistant Attending the Endocrinology Service at Memorial Sloan Kettering Cancer Center. As a researcher, he is a specialist in using observational data (rather than clinical trial data) to study the safety and comparative effectiveness of medical treatments. He collaborates on projects in this area with investigators at Weill Cornell Medical College, Memorial Sloan Kettering Cancer Center, the Perelman School of Medicine at the University of Pennsylvania, and the Food and Drug Administration. Some specific areas that he studies are the safety and tolerability of metformin (the most widely used diabetes medication) and the optimal choice of second-line drugs for diabetes after metformin. Methodologically his particular interests include the analysis of ‘messy’ longitudinal biomarker data using mixed linear models, missing data issues, instrumental variables, and simulation of clinical trials using observational results.