Jacqueline C. Bresnahan BA, MA, PhD

Dr. Bresnahan's research focuses on understanding the biological underpinnings of neurotrauma, particularly spinal cord injury, with the goal of improving recovery for individuals who suffer damage to the nervous system. Her laboratory has developed a number of models to study cellular systems and behavioral changes that occur as a consequence of injury. Her major research interests are cell death mechanisms, including excitotoxicity; regeneration and repair (especially of oligodendrocytes — the glial cells that produce myelin); neuroprotection; transplantation; and mechanisms of functional recovery after cervical spinal cord injury in both rodent and primate models.
Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release 2012;161(3):910-917.
Stuck ED, Christensen RN, Huie JR, Tovar CA, Miller BA, Nout YS, Bresnahan JC, Beattie MS, Ferguson AR. Tumor necrosis factor alpha mediates GABA(A) receptor trafficking to the plasma membrane of spinal cord neurons in vivo. Neural Plast 2012;2012:261345.
Gensel JC, Tovar CA, Bresnahan JC, Beattie MS. Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. PLoS One 2012;7(3):e33519.
Nout YS, Rosenzweig ES, Brock JH, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Courtine G, Ferguson AR, Edgerton VR, Beattie MS, Bresnahan JC, Tuszynski MH. Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury. Neurotherapeutics 2012;9(2):380-92.
Sorani MD, Beattie MS, Bresnahan JC. A Quantitative Analysis of Clinical Trial Designs in Spinal Cord Injury Based on ICCP Guidelines. J Neurotrauma 2012;29(9):1736-46.
Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, Brock JH, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC. Methods for Functional Assessment After C7 Spinal Cord Hemisection in the Rhesus Monkey. Neurorehabil Neural Repair. 2012 Feb 13.