Jaclyn A. Biegel PhD, FACMG

Jaclyn A Biegel, Ph.D., FACMG is the Division Chief of Genomic Medicine and the Director of the Center for Personalized Medicine in the Department of Pathology and Lab Medicine at Children’s Hospital Los Angeles. She is a Professor of Clinical Pathology (Clinical Scholar) at the Keck School of Medicine at the University of Southern California. Dr. Biegel received her Ph.D. in Human Genetics at the University of Pittsburgh, completed a fellowship at Duke University School of Medicine, and rose through the ranks to Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Biegel is an internationally renowned leader in pediatric cancer genetics. She founded the Clinical Cancer Cytogenetics Laboratory at The Children’s Hospital of Philadelphia, where she focused on the development of state of the art testing for children with hematologic and solid tumors.

She is an internationally recognized leader in the field of pediatric brain tumor research, known for her work identifying germline and acquired alterations of the SMARCB1/INI1 gene in the development of the central nervous system (CNS) rhabdoid tumors, and the KIAA1549-BRAF fusion in pediatric low-grade gliomas of the CNS. Dr. Biegel’s approach has truly been a bench to bedside strategy, beginning with the identification of key targets and methods in the research laboratory, and successively developing and validating protocols in the CAP/CLIA environment for clinical implementation.