The DiMaio laboratory is studying the molecular mechanisms of how two groups of tumor viruses, human papillomaviruses and polyomaviruses, enter cells, with a particular focus on identifying the cellular proteins that mediate virus entry and intracellular trafficking. In addition, they are using viral transmembrane proteins as models to develop a class of artificial small transmembrane proteins with a variety of biological activities, including the ability to form tumors and confer resistance to HIV infection.
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