Barbara L. ShacklettPhD
Prof. Barbara Shacklett is extensively working in mucosal immunity and her laboratory is recognized for developing and applying innovative approaches to study mucosal immunity to HIV. Over the past 15 years, her work has helped elucidate the relationship between mucosal T-cell responses and immune control of HIV infection, both in human cohorts and in the nonhuman primate model (SIVmac). This work has included studies of HIV “Elite” Controllers, the role of mucosal regulatory T-cells (Treg), mucosal immune reconstitution in individuals on combination antiretroviral therapy (cART), and mucosa-associated invariant T-cells (MAIT cells).
Her group also studies the female reproductive tract, including hormonal regulation of innate and adaptive immune responses and the impact of menstrual cycle phases on host defense. She has coauthored over 80 peer-reviewed publications, served on grant review panels in the US, France, and Canada, and is currently an Advisor to the California HIV/AIDS Research Program (CHRP) and an Associate Editor of Mucosal Immunology.