Ania Jastreboff MD, PhD

Ania M. Jastreboff, MD, PhD, is the Harvey and Kate Cushing Professor of Medicine and Professor of Pediatrics at Yale School of Medicine. Dr. Jastreboff is a clinically active physician-scientist and international thought leader in the scientific development and clinical application of novel anti-obesity pharmacotherapeutics revolutionizing obesity treatment. As founding director of the Yale Obesity Research Center (Y-Weight), she is leading and shaping pivotal landmark studies of dual- and triple-receptor hormone agonists and NIH-funded studies investigating the physiology of obesity.

She has served as lead investigator and author for trials investigating novel nutrient-stimulated hormone (NuSH)-based therapies for obesity including dual hormone receptor agonist, tirzepatide, a GIP/GLP-1 receptor agonist (Jastreboff, et al., NEJM, 2022 & NEJM, 2024), triple hormone receptor agonist, retatrutide, a GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al., NEJM, 2023), and a monthly monoclonal antibody peptide conjugate, maridebart cafraglutide, a GIP receptor antagonist GLP-1 receptor agonist (Jastreboff, et, al., NEJM, 2025).

Trained in both adult endocrinology and pediatric endocrinology, she has served on the Board of Governance for The Obesity Society, as a director on the American Board of Obesity Medicine, and has helped in the development of Obesity Clinical Practice Guidelines. She serves as co-director of the Yale Center for Weight Management, where she sees patients. She is a highly sought-after speaker, teaching internationally, nationally, and locally. She is a compassionate advocate for patients with obesity, from grass-roots patient groups to interviews with Ms. Oprah Winfrey on CBS Sunday Morning, TODAY, and The View. She is also a New York Times Best-Selling author of Enough: Your Health, Your Weight, and What It’s Like to Be Free by Ania M. Jastreboff, MD, PhD, and Oprah Winfrey.