OVERVIEW

Reducing the Burden and Transforming Outcomes for Patients With Beta Thalassemia is organized by i3 Health.

Start Date: June 16, 2026
End Date: June 15, 2027

Description:
Beta thalassemia is a rare genetic disorder characterized by impaired hemoglobin synthesis and chronic anemia, historically requiring lifelong transfusion and iron chelation protocols. While these conventional treatments are life-saving, they impose a heavy time, treatment, and quality-of-life burden on patients. With gene editing therapies and a rapidly expanding pipeline of novel disease-modifying agents, the multidisciplinary team faces a new clinical landscape. These breakthroughs offer the potential for reduced transfusion burden or even transfusion independence, but they bring complex considerations regarding regimen individualization, lifelong care planning, and long-term safety (Njeim et al, 2024; Hu et al, 2024). To optimize care from childhood through adulthood, the multidisciplinary team must be equipped to personalize treatment for patients using shared decision making. This Interactive Case Consult features Hanny Al-Samkari, MD, the Peggy S. Blitz Endowed Chair in Hematology/Oncology and the Co-Director of the Hereditary Hemorrhagic Telangiectasia Center at Massachusetts General Hospital, and Sherif Badawy, MD, MS, MBA, the Director of the Comprehensive Adult and Pediatric Thalassemia Program at Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, as they explore evidence-based strategies for reducing treatment burden and transforming outcomes for patients with beta thalassemia.

Learning Objectives:
Upon completion of this activity, participants should be able to:

Apply monitoring and management strategies that ensure adequate chelation for patients with beta thalassemia.
Evaluate the clinical utility of current and emerging treatments for transfusion-dependent beta thalassemia (beta TDT) and non–transfusion-dependent beta thalassemia (beta NTDT).
Appraise strategies to optimize therapeutic selection and implementation for individual children, adolescents, and adults with beta thalassemia.

State-required Topic(s)

ACCREDITATION & CREDITS

JOINTLY ACCREDITED PROVIDER
In support of improving patient care, i3 Health is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

PHYSICIANS
i3 Health designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

By providing this information, participants are agreeing to allow i3 Health to share this information with the ACCME.

Physician Assistants/Associates
i3 Health has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 1.5 AAPA Category 1 CME credits. Approval is valid until 6/15/27. PAs should only claim credit commensurate with the extent of their participation.

Nurse Practitioners
The American Academy of Nurse Practitioners Certification Program (AANPCP) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Individuals are responsible for checking with the AANPCP for further guidelines.

Nursing Continuing Professional Development
A maximum of 1.5 ANCC contact hours may be earned by learners who successfully complete this nursing continuing professional development activity. This activity has been designated for 1.5 contact hours of pharmacology credit for Advanced Practice Registered Nurses.

Provider approved by the California Board of Registered Nursing, Provider Number 15824, for 1.5 ANCC contact hours.

Continuing Pharmacy Education
i3 Health has approved this knowledge-based activity for 1.5 ACPE CE hours. The Universal Activity Number for this activity is JA0008128-0000-26-004-H01-P. Pharmacy CE credits can be submitted to the NABP upon successful completion of the activity and the evaluation by providing your NABP ID and DOB, which must be submitted within 60 days of completion.

1.5 AMA PRA Category 1 Credits™

1.5 MOC

1.5 AAPA

1.5 Contact Hours

1.5 CE Hours

FACULTY

Hanny Al-Samkari

MDHematology, Medical Oncology, Internal Medicine

Sherif Badawy

MD, MS, MBAPediatrics, Pediatric Hematology - Oncology

TARGET AUDIENCE

PhysicianNursingPharmacistPhysician AssistantNursesHematologistsAdvanced Practice Providers Other Healthcare Professionals

SPECIALITIES

Haematology

TERMS & CONDITIONS

DISCLOSURE OF RELEVANT FINANCIAL INFORMATION WITH INELIGIBLE COMPANIES
i3 Health endorses the standards of the ACCME, ANCC, and ACPE that require everyone in a position to control the content of a CME/NCPD/CPE activity to disclose all financial relationships with ineligible companies that are related to the content of the CME/NCPD/CPE activity. CME/NCPD/CPE activities must be balanced, independent of commercial bias, and promote improvements or quality in healthcare. All recommendations involving clinical medicine must be based on evidence accepted within the medical profession.

A conflict of interest is created when an individual has an opportunity to affect CME/NCPD/CPE content about products or services of an ineligible company with which he/she has a financial relationship, which therefore may bias their opinions and teaching. This may include receiving a salary, royalty, intellectual property rights, consulting fee, honoraria, stocks, or other financial benefits.

i3 Health will identify, review, and mitigate all relevant financial relationships that speakers', authors, or planners disclose prior to an educational activity being delivered to learners. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation. i3 Health does not endorse any products or services.

Relevant financial relationships exist between the following individuals and ineligible companies:

Hanny Al-Samkari, MD, discloses that he has served as a consultant for Agios, Alnylam, Alpine, Amgen, Atavistik, Diagonal, Novartis, Pharmacosmos, Sobi, Sanofi, Takeda, Tectonic, Terremoto, and Vaderis; and that he has received grants/research support from Agios, Alnylam, Amgen, Novartis, Sobi, Terremoto, and Vaderis.

Sherif Badawy, MD, MS, MBA, discloses that he has served as a consultant for Agios, Beam, Chiesi, Sobi, and X4.

The i3 Health planners, reviewers, and managers have nothing to disclose.

i3 Health has mitigated all relevant financial relationships.

INSTRUCTIONS TO RECEIVE CREDIT
In order to receive credit for this activity, participants must watch the video and submit a completed evaluation at the end of the activity.

COMMERCIAL SUPPORT
This activity is supported by a medical education grant from Vertex Pharmaceuticals Incorporated.

Aggregate participant data will be shared with commercial supporters of this activity.

CONTACT INFORMATION
Technical queries or questions regarding activity credit should be directed to i3 Health at support@emedevents.com.

DISCLAIMER

The information provided at this CME/NCPD/CPE activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition.