OVERVIEW

Pharmacogenomics Primer is organized by University of Florida College of Pharmacy.

Expiration Date: Oct 03, 2020

Accreditation:
Contact Hours: 2.75

Summary:
This course will summarize the principles of drug metabolism pharmacogenetics and genetic medicine.

Course Objectives:
Pharmacogenetics of Drug Metabolism: Parts 1-5
Summarize scientific principles of pharmacogenomics, including discussion of:
• Human genetics.
• Relationship between genotypes and phenotypes in the context of pharmacogenomics.
• Types of polymorphisms, including single nucleotide polymorphisms.
• Linkage disequilibrium.
• Haplotypes and diplotypes.
• Star-allele nomenclature.
• Discuss the different types of studies in the pharmacogenomics literature and their corresponding levels of evidence.
• Explain the contribution of pharmacokinetics and genetics to interindividual variability in response.
• Discuss relevant genetic polymorphisms of important drug metabolizing enzymes and their potential clinical implications.
• Explain the function and tissue distribution of drug transporters.
• Discuss variations in drug transporters and their clinical significance.
• Compare pharmacogenetics and therapeutic drug monitoring (TDM).
• List example drugs for which pharmacogenetics-guided TDM may be the most useful.

Principles of Genetic Medicine: Parts I-2
• Review DNA.
• Explain the Human Genome Project.
• Discuss the Central Dogma of Molecular Biology.
• Discuss the Types of polymorphisms.
• Define allele, genotype, and phenotype
• Define linkage disequilibrium, haplotype, and diplotype
• Introduce PharmGKB

Additional details will be posted as soon as they are available.