Identifying and Managing Patients with Monogenic Diabetes

Identifying and Managing Patients with Monogenic Diabetes is organized by The University of Chicago - Center for Continuing Medical Education.

Activity Created: 06/21/2023
Activity expires: 06/21/2025

Description:
Monogenic diabetes mellitus (MDM) refers to a number of diverse disorders caused by inherited and sporadic single-gene mutations leading to isolated and syndromic cases of diabetes. Monogenic diabetes is a relatively rare but important cause of diabetes. It accounts for an estimated 1-2% of all diabetes cases. Many patients with monogenic diabetes are incorrectly diagnosed with type 1 diabetes (T1DM) or type 2 diabetes (T2DM). Correctly distinguishing people with monogenic diabetes from those with the more typical polygenic forms has important implications for disease management and heritability. In this way, correctly identifying the genetic basis of diabetes allows for clarification of optimal disease management and can elucidate conditions associated with different genetic causes of diabetes. Diagnosing single-gene causes of diabetes also has important genetic implications for patients’ families. Uncovering monogenic forms of diabetes allows for the screening and identification of carriers before the onset of diabetes and provides opportunities for genetic counseling and education.

This series of on-demand webinars provides a unique opportunity to reach a wider audience of healthcare professionals with limited knowledge about the identification and management of monogenic diabetes. It provides healthcare professionals with a comprehensive overview of MDM. The curriculum will include strategies to diagnose MDM, manage its common forms and syndromic forms, and employ genetic testing.

Learning Objectives:
After completing this series, participants will be able to:
•Recall the biochemical and pathophysiologic mechanisms of monogenic diabetes and its various forms;
•Identify specific genetic testing used for MDM diagnoses;
•List other conditions, diagnoses, and syndromes related to MDM;
•State how specific strategies can be used to optimize care and quality of life;
•Describe the mechanism of action of oral therapies and how they may be used to better care for patients with specific types of MDM;
•Discuss clinical features that can be used to identify patients that may have MDM;
•Explain the impact a correct diagnosis can have on MDM treatment and management.