Current Standards and New Directions in the Treatment of Acquired Thrombotic Thrombocytopenic Purpura

Current Standards and New Directions in the Treatment of Acquired Thrombotic Thrombocytopenic Purpura is organized by i3 Health.

Dates Available:
July 25, 2023 - July 24, 2024

Statement Of Need:
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare, life-threatening thrombotic microangiopathy with a rapid onset and progression and a mortality rate of 10% to 20% with prompt treatment. The onset of aTTP is characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, and a constellation of associated symptoms including hemorrhage, neurologic and renal manifestations, cardiac abnormalities, and mesenteric ischemia (Joly et al., 2017). Survivors of first aTTP events tend to have relapse events that need to be controlled. Rapid recognition and immediate appropriate treatment are critical for achieving optimized outcomes in aTTP. In this activity chaired by Spero Cataland, MD, Professor of Clinical Internal Medicine and Director of Benign Hematology at The Ohio State University, expert faculty will provide insightful guidance on current treatment standards and will discuss emerging therapies with the potential to improve patient outcomes in aTTP. 

Learning Objectives:
Upon completion of this activity, participants should be able to

• Evaluate the clinical and laboratory features of aTTP that can inform timely and accurate diagnosis
• Discuss how ADAMTS13 activity can be used to guide the management of aTTP
• Assess the mechanism of action, efficacy, and safety of novel anti-von Willebrand factor nanobodies in aTTP as elucidated by recent clinical trials
• Evaluate novel treatment combinations and sequences with the potential to improve the outcomes of patients with aTTP

Faculty:
Spero R. Cataland, MD
Professor of Internal Medicine
Division of Hematology, Benign Hematology Section Head
Wexner Medical Center at The Ohio State University

Gain insight and expertise in this discussion on acquired thrombotic thrombocytopenic purpura. Spero Cataland, MD, Professor of Clinical Internal Medicine and Director of Benign Hematology at The Ohio State University, will provide guidance on current treatment standards and will discuss emerging therapies with the potential to improve patient outcomes in aTTP.