OVERVIEW

Why Use Humanized Mouse Models for Translational Studies in Inflammatory Disorders is organized by XTalks and will be held on Jan 24, 2023.

Description:
The drug development process strongly relies on the predictivity of preclinical mouse modeling. Humanized mouse models, i.e., mouse models that recapitulate human components are therefore highly valuable translational tools.

In this webinar, the featured speakers will showcase drug testing in humanized mouse models in two therapeutic areas: food allergy and inflammatory bowel diseases (IBD): Inflammatory bowel diseases, which include ulcerative colitis and Crohn’s disease, are characterized by a chronic inflammation of the intestinal tract. Even though conventional treatments such as immune modulators might improve the symptoms, a high number of patients do not respond to the available treatments.

In the first part of the webinar, Dr. Ho Wang Yin, PhD, CIO will show how humanized mouse models help develop new therapies for IBD. She will provide an overview of chemically induced models of acute colitis (DSS and TNBS), the pros and cons of each model and a summary of typical study design. Peanut allergy affects up to two percent of the pediatric population and is a high unmet medical need as peanut ingestion is the most common cause of food induced anaphylaxis in the US. Oral immunotherapy, the only US Food and Drug Administration (FDA) approved therapy, is lengthy and carries the risk of serious side effects. In the second part of the webinar, Dr. Wuillemin will demonstrate the efficacy of MY006, a passive immunotherapy developed thanks to Mabylon’s unique antibody discovery platform, for the treatment of peanut allergy in humanized mouse models. Register for this webinar to explore the importance of using humanized mouse models for translational studies in inflammatory disorders.

What You Will Learn:
Attendees will learn:

The main characteristics of a full human immune system mouse model
The pros and cons of two different IBD colitis models: DSS (dextran sodium sulfate) vs TNBS (2,4,6-Trinitrobenzene sulfonic acid)
Humanized mouse models for allergy