Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions

Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions is organized by MediaLab, Inc.

Course Overview:
This collection of informative case studies covers many current topics in red cell disorders. Topics include macrocytosis, intracellular RBC inclusions, echinocytes and acanthocytes, schistocytes, ovalocytes, and rouleaux. Numerous high-quality photomicrographs and real-life situations help ensure learning and retaining needed information.

Objectives:
• Review normal and abnormal red blood cell morphologies.
• Recall the criteria for performing and reporting peripheral blood smear reviews.
• Demonstrate ability to evaluate red blood cell size, shape, and staining characteristics.
• Correlate observations of key red blood cell abnormalities on peripheral smears with associated clinical conditions.
• Recognize, via case studies, peripheral smear evaluations for red blood cell morphology and their clinical implications.

Course Outline:
• Introduction to Red Blood Cell Morphology
  • Normal Red Blood Cell Morphology
    • Normal Red Blood Cell (RBC) Characteristics
    • Initial Evaluation of RBC Morphology From Automated Analyzers
    • Criteria for Peripheral Blood Smear Review
  • The Peripheral Smear: Reviewing Red Blood Cell Morphology
    • Introduction to Red Blood Cell Morphology Reporting
    • Guidelines for Reporting Red Blood Cell Morphology
• Abnormal Red Blood Cell Morphology Review
    • Red Cell Morphology Reference Tables
  • Size Variations in Red Blood Cells
    • Anisocytosis Reference Table
  • Variations in Hemoglobin Content
    • Hemoglobin Content Reference Table
  • Shape Variations in Red Blood Cells
    • Poikilocytosis Review Table
  • Abnormal Red Blood Cell Distribution
    • Rouleaux and Agglutination
    • Dimorphic (Double Cell) Population
  • Red Blood Cell Inclusions
    • Red Blood Cell Inclusions and Associated Conditions
• Case Studies in Red Blood Cell Nonneoplastic Conditions
    • Introduction to Red Blood Cell Nonneoplastic Conditions Case Studies
  • Hemolytic Conditions with Spherocytosis
    • Hemolytic conditions with spherocytosis: Case Study OneA 12-year-old child presents with jaundice and scleral icterus. The image to the right captures...
    • Hemolytic conditions with spherocytosis: Case Study One, continued:Which hematologic condition could be associated with the findings shown in this ima...
    • Hemolytic conditions with spherocytosis: Case Study Two A known case of hemolytic disease of the newborn (HDN) is presented in the image on the right....
    • Hemolytic conditions with spherocytosis: Case Study ThreeA 49-year-old male with pneumonia was treated with high-dose intravenous penicillin. He becam...
  • Macrocytosis-Associated Conditions
    • Macrocytosis-associated conditions: Case Study One A complete blood count (CBC) was ordered for a patient recently admitted to the emergency departmen...
    • Macrocytosis-associated conditions: Case Study TwoA patient has an elevated MCV on the automated CBC and a peripheral blood smear is reviewed. A repre...
  • Intracellular RBC Inclusions
    • Intracellular RBC inclusions: Case Study OneA twenty-five-year-old asplenic male with disseminated lymphoma is admitted to the hospital. A CBC is orde...
    • Intracellular RBC inclusions: A toddler is being treated for lead poisoning. You observe the inclusions indicated by the arrows in many RBCs on the pe...
    • A 66-year-old man has been diagnosed with sideroblastic anemia. The inclusions indicated by the arrows in the image were seen in many of the RBCs on h...
    • A ten-year-old boy came to a physician's attention because of recent jaundice and icteric sclerae after taking the medication Primaquine. The immediat...
  • Dimorphic Red Blood Cell Populations
    • A blood smear represented by the photograph was submitted for hematologic review. Based on the erythrocyte morphology and the accompanying histogram, ...
  • Target cells and Sickle Cells
    • Hemoglobin E (HbE) and HbE/Beta Thalassemia
    • Case Study A five-month-old Asian child is brought to the pediatrician by her mother who is concerned because the child is not eating well. Upon exami...
    • A CBC and reticulocyte count are ordered on a 10-year-old African-American male who was brought to the emergency department with rapid, shallow breath...
    • Sickle cells along with target cells, as shown in this image, confirm a diagnosis of sickle cell disease (HbSS).
  • Schistocytes, Bite Cells, and Teardrop Cells
    • Case Study A patient is diagnosed with disseminated intravascular coagulation (DIC) based on clinical findings and laboratory results that include dec...
    • The top image on the right represents a Wright-stained microscopic field from a peripheral blood smear. The bottom image represents a microscopic fiel...
    • The cells indicated by the arrows provide a clue to the diagnosis of chronic idiopathic myelofibrosis (primary myelofibrosis). What is the identity of...
    • A 5-year-old girl was brought to the emergency department with bloody diarrhea and severe abdominal pain. A complete blood count produced these result...
  • Ovalocytes, Elliptocytes and Stomatocytes
    • Ovalocytes/Elliptocytes
    • Stomatocytes
    • Case StudyA 13-year-old healthy male presents to his physician for a sports physical. A complete blood count (CBC) is ordered. The automated count tri...
  • Multiple Erythrocyte Abnormalities
    • Case Study
    • Case Study, continued: Splenectomy Morphologies
    • Case Study, continued: Poikylocytosis and Basophilic Stippling
    • This slide is from a 28-year-old female who received a kidney transplant, which was preceded by a splenectomy six months prior to the kidney transplan...
• References
    • References