OVERVIEW

Evaluating the Impact of Induction and Consolidation Total Neoadjuvant Therapies Compared to Conventional Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Network Meta-analysis is organized by Lippincott CME Connection.

Published: June 2025
Expires: 06/01/2028

Description:
As you prepare to participate in this activity, please reflect on your practice and your patients and identify clinical challenges you hope to have addressed.

While participating in the training, identify ways you can use newly acquired knowledge, strategies, and skills to enhance patient outcomes and your own professional development.

Learning Objectives:
After completing this continuing education activity you will be able to:

Delineate how Total Neoadjuvant Therapy (TNT) regardless of treatment sequence, results in higher pathologic complete response rate than chemoradiation (CRT) followed by total mesorectal excision.
Outline how prolonging neoadjuvant treatment before resection does not seem to cause increased treatment-related toxicity or postoperative morbidity.
Discuss whether TNT translates to better long-term oncologic outcomes remains unclear due to the short-term follow-up in many of the studies included in this meta-analysis