OVERVIEW

Mechanisms of Drug Resistance and Tolerance in Bacteria, Fungi and Cancer is organized by European Molecular Biology Laboratory (EMBL) and will be held from Mar 18 - 21, 2025 at EMBL Advanced Training Centre (ATC), Heidelberg, Baden-Wurttemberg, Germany.

Description:
Resilience to antimicrobial drugs is a rapidly increasing problem of global health. Similarly, cancer cells that become drug-resistant or tolerant affect therapy outcomes, for instance during cancer chemotherapy. The underlying biological mechanisms of tolerance, resistance, and persistence are increasingly being studied and reveal a complex interplay between (cellular) evolution, biochemistry, and metabolism. Understanding these mechanisms holds the long-term promise of developing new therapeutic strategies less prone to drug resistance and, in the short term, enhances our understanding of clonal evolution and single-cell biology. With this new symposium, we aim to gather a highly international group of researchers to exchange in person the latest work on the biological mechanisms that mediate drug resistance and tolerance across the species barriers.

Session topics

Molecular targets and mechanisms of tolerance and resistance
Resistance and tolerance mechanisms of microbiomes and commensals
Resistance and tolerance mechanisms, single cell biology, persistence & clonal evolution
Resistance and tolerance mechanisms: the role of efflux and drug transport
Molecular genetics of resistance and tolerance mechanisms
The role of macro- and microenvironment on resistance & tolerance mechanisms