Covalent Modulation in Drug Discovery

Covalent Modulation in Drug Discovery is organized by British Pharmacological Society (BPS) and will be held from Oct 07 - 08, 2026 at The Discovery Centre (DISC) - AstraZeneca PLC, Cambridge, England, United Kingdom.

Description:
Covalent modulation is a crucial part of the drug discovery toolbox and is an important strategy for finding tractable equity against less druggable targets. However, understanding the binding kinetics, mechanistic PK/PD relationship and SAR of compounds is critical to success as is employing best practice in hit identification, lead optimisation and candidate selection. The conference will feature the latest developments in covalent hit identification and optimisation, including the targeting of cysteine and other amino acid residues. There will be in depth analysis of the data needed to generate covalent dug candidates and discussion around best practices in the field.

Learning Outcomes: 
Our expectation is that the meeting may serve to:

• Build a network amongst researchers interested in irreversible modulation in drug discovery
• Establish the framework for understanding kinetics in drug discovery for covalent binders
• Enable researchers to better find, understand and optimise covalent chemical tools, leads and drug candidates