Humanized Mice: Immunotherapy and Regenerative Medicine

Humanized Mice: Immunotherapy and Regenerative Medicine is organized by European Molecular Biology Laboratory (EMBL) and will be held from Nov 17 - 22, 2024 at EMBL Advanced Training Centre (ATC), Heidelberg, Baden-Wurttemberg, Germany.

Description:
Humanized mouse models became an integral part of basic and translational biomedical research for the understanding of human pathologies and for development of new therapies. Human cells or tissues implanted in mice can reflect human hematopoiesis, immunity, oncology, infections, physiology and genetic polymorphisms. The development of immunotherapeutic drugs, cell and tissue therapies rely on the preclinical testing to assess their potency and safety. “Big pharma” and biotech companies include humanized mice in the non-clinical development portfolio. Humanized mouse models have varied among laboratories regarding the use of new transgenic and knock-out strains, improved handling methods, innovative sources and manipulation techniques of the human graft material and novel technological platforms for analyses.

The topics of this course are immune reconstitution, oncology, immuno-oncology, regenerative medicine and infections. We will update the participants about different case-by-case models starting with the basic science, and how to best explore these models with accurate data acquisition and reporting. We aim to instruct the principles of experimental pre-requisites for data recording and harmonized analyses within the field. Techniques and results will be presented and discussed in sessions, round tables will focus on ethics requirements for animal handling and human tissue collections. Social activities will boost networking among international participants.

Modules:

• Human hematopoiesis and immunity in mice
• Human tumor models
• Human immuno-oncology in vivo from basics to applications
• Regenerative medicine: gene therapy, gene editing, induced pluripotent stem cells and the liver
• Infections