Ubiquitin Signaling (X3) 2016 is organized by Keystone Symposia on Molecular and Cellular Biology and would be held during Mar 13 - 17, 2016 at Whistler Conference Centre - Whistler, British Columbia, Canada. The meeting will focus on how ubiquitylation controls processes such as autophagy, neurodegenerative diseases, hypertension, the immune system and the activation of NF-kappaB. It will include talks on how the ubiquitin system is controlled by protein phosphorylation, the specificity and regulation of deubiquitylases and the structural analysis of E3 ligases and large protein complexes that coordinate ubiquitylation and related events.