The theme for this year's conference is how evidence based therapy and welfare support will fare in a climate of austerity. As ever our line up of keynote speakers is unrivalled. They are also set for a fascinating discussion about the place of evidence based guidelines and the role of NICE, in particular, in the run up to a new Depression guideline in the making. Professor David Healy, a leading scientist in depression research, as well as a severe critic of the influence of the pharmaceutical lobby, will deliver the closing keynote on day 1, offering a radical critique of NICE"s evidence based guidelines. Professor David Haslam, Chair of NICE, will deliver our opening keynote on day 2, defending the vital importance of an independent body for quality standards, without which health inequalities would worsen.