NF-kappaB and MAP Kinase Signaling in Inflammation (X4) 2016 is organized by Keystone Symposia on Molecular and Cellular Biology and would be held during Mar 13 - 17, 2016 at Whistler Conference Centre - Whistler, British Columbia, Canada. This symposium will focus on the role of ubiquitination in regulating NF-kappaB and MAP kinase activation, and how NF-kappaB-dependent transcription is coordinated with IRF activation and MAP kinase signaling to control innate immunity. Dysregulated inflammatory responses underlie many major diseases, including arthritis, psoriasis, inflammatory bowel disease, atherosclerosis, metabolic disease and cancer.