The BioIron Meeting is the main international forum for the comprehensive presentation and discussion of cutting-edge advances in the biology of iron and the role of iron in medical science. During the last two decades research has progressed rapidly and has elucidated essential molecular mechanisms that regulate cellular and systemic iron metabolism and homeostasis. All previous BioIron meetings have witnessed exciting progress and discoveries that are now translated from bench to bedside. The knowledge gained has had a major translational impact in traditional iron-related disorders such as iron overload and deficiency. Furthermore, an essential role for iron has been recognized in other common disorders, including cancer, cardiovascular, inflammatory and neurodegenerative disorders.