The causative links between genomic and genetic variations and cancer are well documented and have provided a greater understanding of tumorigenesis and cancer progression. Molecular genetic information has been used to derive new therapeutic regimens and has accelerated the development and application of "personalised cancer medicine". There are also an increasing appreciation that epigenetic aberrations that are often directly caused by genetic defects resulting in loss- or gain-of-function of epigenetic-regulators also contribute significantly to cancer onset and progression. Indeed, parallel integration of our knowledge of the cancer genome and epigenome using sophisticated "omics-based" technologies and high throughput functional screening techniques are providing even more tangible links between genetic/genomic aberrations, epigenetic/epigenomic dysregulation and tumorigenesis.