New Frontiers in the Discovery and Treatment of Thrombosis (A6)

During the last several decades, there has been unprecedented growth in the fundamental understanding of coagulation and platelet function. The logical evolution of these discoveries has been the development of a wide array of therapies targeting platelet receptors and pathways within coagulation to treat thrombotic diseases.
Although clearly successful, the evolution of these agents is at a crossroads due to limitations and questions including hemorrhage and pleiotropic effects. The goal of this symposium is to explore new discoveries in thrombosis and consider their potential for translation relative to existing/developing therapies.
This symposium will focus on:
1) Understanding how fundamental mechanisms regulating vascular disease risk factors and genetics modulate coagulation;
2) Investigating how these processes influence platelet-dependent thrombosis and vessel wall interactions; and
3) Determining how the evolution of treatments for thrombosis has led to a new appreciation of the complex interactions between coagulation and thrombosis, and how this may guide the use of new and existing therapies.
This meeting will bridge clinical and basic investigators to discuss a rapidly evolving field. The goal is to gain a greater appreciation of the novel discoveries in the areas of vascular occlusion, the treatment of thrombosis and the minimization of risk.