Search Criteria : United States of America Breckenridge
Sep 20 - 24, 2020 | USD $1095 | Breckenridge, Colorado
Genomic Stability and DNA Repair is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Sep 20 - 24, 2020 at Beaver Run Resort & Conference Center, Breckenridge, Colorado, United States of America. Course Description: This conference seeks to connect emerging mechanisms of DNA repair and replication with genome stability. The significance and complexity of the DNA damage response cannot be understated, with a central role in reproduction, development, and genome evolution, as highlighted by the many human disease states that occur from genome instability stemming from DNA repair deficiency. The scientific program reflects the importance of classical processes such as DNA replication and homology directed DNA repair in genome integrity, while highlighting emerging aspects of the DNA damage response involving noncoding RNA, chromatin recognition and organization, and catastrophic rearrangements that emanate from mitosis. An additional area of innovation is the realization that genome stability influences human physiology through its signaling to metabolism, the immune system, hematopoietic stem cells, and developmental biology. We will emphasize the importance of fundamental DNA repair mechanisms to organismal biology in normal and pathophysiological states, including opportunities to exploit the DNA damage response for therapeutic gain and genome engineering. The scientific program encompasses two keynote speakers, eight plenary sessions and four workshops, that collectively, represent the most exciting aspects of the field and bring together a scientifically diverse group of international investigators to promulgate interdisciplinary areas of exploration. Additional details will be posted as soon as information is available.
Jan 24 - 28, 2021 | USD $1095 | Breckenridge, Colorado
Tumor Metabolism and the Microenvironment is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Jan 24 - 28, 2021 at Beaver Run Resort & Conference Center, Breckenridge, Colorado, United States of America. Description: As we know, cancer is a major cause of mortality worldwide. Furthermore, cancers result from mutations within somatic cells; however, their evolution and phenotype are determined by their environment, both local and systemic. Increased understanding of mechanisms that drive cancer will provide new avenues to reduce incidence and to treat the disease. Therefore, this meeting brings together researchers focusing on how nutrient availability and utilization influences tumors and those thinking about the multitude of inter-cellular interactions occurring within tumors. The inter-connections between these fields are becoming ever more apparent and this meeting unites the fields of tumor metabolism and the tumor microenvironment together, sparking new synergies and connectivity between researchers. With the extensive opportunities for discussion and numerous short talk slots on the program, this conference will help nurture early career scientists, the next generation of talent, and lead to the emergence of collaborative networks. Moreover, there is an afternoon workshop on “Transitioning to Independence” for early career researchers. Finally, a thorough understanding of how tumor systems can adapt and re-wire in response to challenges is needed to ensure that new therapies being developed have the best chance of success as they enter clinical trials. To that end, several speakers have been selected with the expectation that they discuss either clinical trial data. This will strengthen the linkage between cutting-edge mechanistic studies and human disease. Additional details will be posted as soon as information is available.
Skin-Immune Crosstalk is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Feb 15 - 18, 2021 at Beaver Run Resort & Conference Center, Breckenridge, Colorado, United States of America. Course Description: Skin is a barrier environment where immune cells interact with the unique skin environment to maintain tissue homeostasis and induce immune responses. Skin immune cells can be recruited from the circulation, but many reside in the skin where they are strategically located at the barrier interface within a complex stromal matrix in proximity with commensal bacteria and the external environment. Recent discoveries have radically changed our knowledge of the skin immune system including the interplay between different skin-resident immune cell types and the realization that skin immune cells interact with non-immune compartments in the skin. Skin-resident immune cells are shaped by the cutaneous microbiome and interact with the peripheral nervous system. These complex interactions result in efficient host defense against many pathogens, but some bacteria, fungi, viruses and vector-borne pathogens have evolved mechanisms to evade these systems. This conference will bring together immunologists, skin biologists, and dermatologists to introduce all groups to these new discoveries, challenges, and therapeutic opportunities. We will provide the attendees with a clear understanding that the host skin is a complex environment designed to tolerate commensals and respond to pathogens. Joining with a concurrent vector-borne disease meeting will enable microbiologists and vector biologists to exchange knowledge with immunologists and skin biologists, allowing for consideration of how new discoveries regarding skin-immune cross talk can inform our understanding of vector-borne pathogen transmission. Additional details will be posted as soon as information is available.
Feb 15 - 18, 2021 | USD $1095 | Breckenridge, Colorado
Vector Biology: Emerging Concepts and Novel Technologies is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Feb 15 - 18, 2021 at Beaver Run Resort & Conference Center, Breckenridge, Colorado, United States of America. Course Description: Arthropod vectors transmit several infectious agents that infect millions of people globally and cause over 700,000 deaths annually. Rapid unplanned urbanization, increased travel and trade bring humans into frequent contact with arthropod vectors, while climate change fuels their spread worldwide. Innovative concepts and technologies are strengthening vector control worldwide and redefining how to study these arthropods. Therefore, this Keystone Symposia conference will focus on cutting-edge areas of research, such as synthetic biology, microbiome and immunometabolism. The program was designed to embrace the reinvigorated aspects of arthropod vector epidemiology, physiology and reproduction. Furthermore, this conference is being held jointly with “Skin and Immune Crosstalk at Barrier Surfaces”. Entomologists, immunologists and microbiologists will discuss emerging insights into critical molecular mechanisms that occur at the vector-host interface. This conference will provide a collegial forum for intellectual exchange between investigators at various career levels, which will help to generate original thinking to tackle the complexity of vector biology. Currently, there is no high-profile venue to discuss biological mechanisms and disease transmission that occur and are influenced by arthropod vectors as well as the fundamental interactions between vectors, pathogens and host. The program will develop and explore central paradigms in vector biology, foster collaborations between investigators with distinct expertise and provide mentoring for the next generation of scientists. Additional details will be posted as soon as information is available.
Feb 19 - 23, 2021 | USD $1095 | Breckenridge, Colorado
Mitochondrial Dysfunction: From Ultra-Rare Diseases to Aging is organized by Keystone Symposia on Molecular and Cellular Biology and will be held from Feb 19 - 23, 2021 at Beaver Run Resort & Conference Center, Breckenridge, Colorado, United States of America. Course Description: Mitochondrial dysfunction is associated with conditions ranging from severe, inborn errors of metabolism to the very aging process itself. Inherited mitochondrial diseases are rare and tend to be associated with severe defects in the organelle, while aging and age-associated degeneration is universal and tends to be associated with a more subtle, quantitative decline in mitochondrial function. This Keystone conference will address key questions surrounding mitochondrial pathogenesis. Talks will explore the underlying mechanisms and their specificity, looking at whether therapies developed for orphan diseases can be used to treat age associated disorders and vice versa. By bringing together established and emerging rare mitochondrial disease and aging researchers this conference will explore mechanisms of mitochondrial dysfunction across a vast this continuum. The ensuing cross-fertilization is expected to result in the synthesis of new testable hypotheses that will help to drive the entire field forward. Additional details will be posted as soon as information is available.