Upcoming Medical Conferences in UK

10th Annual RNA Therapeutics Conference is organized by SMi Group Ltd and will be held from Feb 20 - 21, 2019 at Copthorne Tara Hotel London Kensington, London, England, United Kingdom. Conference Description: Fulfilling the potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs and antisense nucleotides, are promising examples of a newer class of biologics. Researchers have tried to overcome the major challenges for utilising RNAs in a therapeutic context, including: intracellular delivery, stability and immunogenicity. Bringing together industry experts, to discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies and present an overview of the applications of RNA-based drugs for modulation of gene and protein expression and genome editing Who Should Attend: Key Job Titles include: • Research & Development Directors/Managers/Scientists • Senior Scientists • Chief Scientific Officers • Chief Medical Officers • Heads of Clinical Development • Heads of Pre-Clinical Development Keynote Speakers: • Ekkehard Leberer, Senior Director, Alliance Management, Sanofi • Shalini Andersson, Senior Director and Head of New Modalities, AstraZeneca • Carsten Rudolf, Chief Executive Officer, Ethris Gmbh • Paul Agris, Founder and Director, The RNA Institute • Marian Gindy, Executive Director, Pharmaceutical Sciences, Merck Research Labs, Merck and Co • David Giljohan, CEO, Exicure • Ingmar Hoerr, Founder and CEO, CureVac AG • David Blakey, Chief Scientific Officer, MiNA Therapeutics • André Gerber, Professor of RNA Biology, University of Surrey • Heinrich Haas, Vice President Drug Delivery, BioNTech RNA Pharmaceuticals • Markus Mandler, Chief Scientific Officer, Accanis Biotech • Troels Koch, Vice President and Head of Research, RNA Therapeutics, Roche • Hans Kistemaker, Associate Director, ProQR Conference Highlights: • Discover the clinical progress of Spherical Nucleic Acids at Exicure • understand Sanofi ’s strategies to deliver therapeutic oligonucleotides across biobarriers • Learn from ProQR how to plan for oligonucleotide supply from personalized medicine to large scale markets • Explore the development of small activating RNA – from bench to bedside with MiNA Therapeutics • Gain insight into the discovery and development of self-amplifying mRNA vaccines at GSK Time: 8:30 am to 5:00 pm Additional details will be posted as soon as they are available.

SMi's 3rd Annual 3D Cell Culture Conference is organized by SMi Group Ltd and will be held from Feb 20 - 21, 2019 at Copthorne Tara Hotel London Kensington, London, England, United Kingdom. Conference Description: Cell Culture in an important tool for research and development within the life science industry. Over the past few years, 3D Cell Culture has gained momentum within the pharmaceutical industry due to the benefits that this model offers over conventional cell culture methods. 3D cell culture enables cells to grow and interact with their surroundings in all three dimensions, better mimicking the in-vivo conditions in which the cells are naturally present. This enhances the ability for scientists to study basic biological mechanisms such as cell number monitoring, cell viability, proliferation and morphology. 3D cell cultures also have greater stability and longer life spans. Highlights in 2019: • Discuss organ-on-chip technologies and their applications in the pharmaceutical industry • Engage in a panel discussion on whether 3D cell culture will replace animal models • Gain insight into the global developments in 3D cell culture and the impact on researchers • Discover the development of 3D eye models for early assessment of retinal toxicity • Explore the use of musculoskeletal regeneration in harnessing preclinical models for tissue repair Early Bird-Rates: • Book by 30th Nov and Save £200 • Book by 14th Dec and Save £100 Time: 8:30 am - 5:35 pm Prices: Conference and Workshop: GBP 2098.0, Conference only: GBP 1499.0, Workshop only: GBP 599.0, Promotional Literature Distribution: GBP 999.0

International Conference on Paradigm Changes in the Management of Early Pregnancy and Pregnancy Loss (PCMEP) is organized by Paragon Group and will be held from Feb 21 - 24, 2019 at Hilton London Wembley, London, England, United Kingdom. The conference is designed for Gynecologists working in early pregnancy, family physicians, geneticists, physicians working in reproductive medicine, and those involved with fetal-maternal care. It is also ideal for nurses, social workers, and others working with early pregnancy, and in early pregnancy units which are especially popular in the U.K. The PCMEP meeting is an international conference on the numerous problems seen in early pregnancy. The conference will cover important and burning topics The conference is divided into six main themes:- Basic mechanisms in early pregnancy development, pregnancy loss, both sporadic and recurrent, the developing pregnancy, management of early pregnancy, and a session on regulation, devoted to what publically funded health services should provide, and women's rights to adequate care in early pregnancy. Each clinical theme will cover new concepts such as the transition from evidence-based medicine to the personalized approach, in recurrent pregnancy loss, the treatment of patients who are refractory to conventional treatment will be covered fully. The management theme will examine the role of treatment modalities, both old and new. Conference Topics: Basic Mechanisms in Early Pregnancy Development: • Genetics in early pregnancy development • Immunology of early pregnancy • Autoimmunity and pregnancy loss • Physiology of hCG • Physiology of progesterone • Thyroid gland in pregnancy Pregnancy Loss: Sporadic and Recurrent: • Antiphospholipid Syndrome • Structural Uterine anomalies Recurrent Pregnancy Loss: • Aetilogy • Investigation protocol • Role of progestogens • Immunotherapy • Pregestational screening The Developing Pregnancy: • Ultrasound in early pregnancy • Threatened miscarriage • Hyperemesis Gravidarum • Molar pregnancies • Choriocarcinoma • Expanded carrier screening • Fetal origins of adult disease • Polycystic ovary syndrome Management: • The role of anticoagulants and aspirin • Surrogacy and its associated problems • Third party reproduction • Ectopic pregnancy • Psychological support • Alternative medicine • Lifestyle factors Regulation: • Right to abortion • What should public health services provide • The use of experimental techniques Time:8:00 am to 5:00 pm Speaker:Howard Carp Additional details will be posted as soon as they are available.

Glasgow Emergency Surgery and Trauma Symposium (GESTS) is organized by Orthopaedic Research UK and will be held from Feb 21 - 22, 2019 at Royal College of Physicians and Surgeons of Glasgow, Glasgow, Scotland, United Kingdom. This CPD Conference has been approved for a maximum of 12 CPD Credits. Conference Description: This two-day symposium brings together a range of nationally and internationally renowned expertise and focuses on key messages and practical tips in emergency surgery and trauma care. The event is structured to concentrate the most insightful updates into a highly focused and well-structured programme with opportunities to ask key questions. GESTS will not only consolidate your existing knowledge, but give you access to expert opinion, topical debate and key updates. Delegate feedback has repeatedly praised the informal nature of the meeting, the short, focused, talks, the case based panel discussions, and the range of speakers. Additional details will be posted as soon as they are available.

Clinical Cases And Michael Feiwel Lecture is organized by The Royal Society of Medicine (RSM) and will be held on Feb 21, 2019 at The Royal Society of Medicine, London, England, United Kingdom. This Conference has been approved for a maximum of 4 CPD Points. Description: The Dermatology Section meetings offer trainees the opportunity to present clinical cases to consultants and trainees for discussion and advice. Run as a series of meetings throughout the year, these meetings allow discussion of both complex and classical dermatological issues. This meeting is from a series of events relating to dermatology clinical cases. For more information please contact the Event Coordinator. Topics include: • Current approaches to diagnosis and management of rare and unusual dermatology conditions • Presentations of common dermatological problems • Recent progress in diagnostics and management of dermatological conditions • The impact of skin disorders on individuals and the importance of a holistic approach to management Additional details will be posted as soon as they are available.

Regional Seminar - Peri-Operative Complications in Anaesthesia - Prevention and Cure is organized by The Association of Anaesthetists of Great Britain and Ireland (AAGBI) and will be held on Feb 21, 2019 at Discovery Point - Dundee Heritage Trust, Dundee City, Scotland, United Kingdom. This Conference has been approved for a maximum of 5 CPD points for attendance. Additional details will be posted as soon as they are available.

14th Annual Biomarkers Congress is organized by Oxford Global Marketing Ltd and will be held from Feb 21 - 22, 2019 at Manchester Central Convention Complex, Manchester, England, United Kingdom. The target audience for this medical event is designed for senior level attendees from leading pharmaceutical, biotechnology, diagnostics, CRO and solution provider companies, alongside highly esteemed members of academic research institutions. The co-located 6th Annual Biomarker in Clinical Development Congress provides a great opportunity for attendees to learn more about the latest status updates about the ever-changing regulatory landscape in clinical development, genomic approaches in drug development, RNAseq NGS in biomarker benchmarking and the advances made in NGS techniques in liquid biopsy. Hear the latest challenges and opportunities in the role of biomarkers in clinical development, clinical trials and clinical diagnostics including implementing clinical biomarkers in auto-immune diseases such as cardiovascular, COPD, immuno-oncology, inflammatory and PK/PD biomarkers to clinical biomarkers. Course Objectives : • Biomarkers in Drug Discovery & Development Therapeutic Areas: Autoimmune, Immuno-oncology, Neuroscience, Oncology, Precision Medicine, Companion Diagnostics, Molecular Diagnostics Development. • Biomarkers in Drug Discovery & Development Therapeutic Areas: Cardiovascular, Rheumatology, Respiratory, COPD, Rare Diseases, Infectious Diseases, Inherited Diseases. • Innovations in Biomarkers Research, Assay Development, Imaging, Data Integration Methods, Bioinformatics, Trial Design Biomarker: Clinical Development & Clinical Trials. • Innovative Biology- NGS & Genomic Markers, Clinical Testing and Diagnostics Development. Additional details will be posted as soon as they are available.

Research: Evidence-Informed Practice is organized by International Chiropractic Pediatric Association (ICPA) and will be held from Feb 23 - 24, 2019 at Holiday Inn London - Heathrow M4,Jct.4, London, England, United Kingdom. The target audience for this medical event is chiropractors and students of 5th quarter/4th trimester or higher. This CME Conference has been approved for a maximum of 12 hours of continuing education credits. CE Credits Request Fee: $45 per class. This fee is additional to seminar cost and is non-refundable. Course Goal: Overview of current published research: understanding the various types of research and essentials of the case history. Application of current research and its relevance to case management in the family practice. Participants will be introduced to the methodology of preparing a case study for publication.​​ To provide the attendee with the most relevant research in the chiropractic care of children and impart the ability to critically appraise and integrate/reconcile the research findings with the chiropractic empirical/clinical experience for the purpose of teaching, research and practice. Additional details will be posted as soon as they are available.

3rd Scientific Workshop on Tumour Microenvironment in the Haematological Malignancies and its Therapeutic Targeting is organized by European School of Haematology (ESH) and will be held from Feb 24 - 26, 2019 at Francis Crick Institute, London, England, United Kingdom. Course Description: This workshop offers highest level science on the nature of the normal and malignant haemopoietic stem cell niche. It also aims to present strategies to target haematological cancers in their tumour microenvironment, thereby combining basic research efforts with possible clinical applications. It is designed to promote scientific interaction between participants from all over the world, involving junior and senior biologists and clinicians working in both the academic and industrial settings. Course Objectives: • Define the currently known complexities of the normal and malignant haematopoietic stem cell niche. • Define the complexities of metabolic changes in the bone marrow microenvironment in health and disease. • Define the effects of inflammatory processes on the bone marrow microenvironment in health and disease. • Define the interaction of haematological cancer cells with their microenvironment and methods to visualize and mimic these. • Define strategies to target the malignant haematopoietic stem cell niche to augment existing therapies.

euroPLX 69 London is organized by RauCon business development and will be held from Feb 25 - 26, 2019 at Sofitel London Heathrow Hotel, London, England, United Kingdom. Additional details will be posted as soon as they are available.