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Yves Pommier

Yves Pommier

    MD, PhD
Chief | Bethesda, Maryland    United States Of America
Biochemistry And Molecular Genetics, Oncology,...More
DNA Topoisomerases In Cancer Chemotherapy, DNA Topoisomerases,...More
Spoken at 1 event

Biography :

Dr. Pommier is a leader on DNA topoisomerase biology and biochemistry, and their cancer relevance. He revealed the interfacial inhibition paradigm based on molecular mechanisms of topoisomerase inhibitors, and has championed its broad relevance for molecular pharmacology and drug discovery. He discovered the indenoisoquinolines as novel Top1 inhibitors, which are in clinical development, and the mitochondrial topoisomerase gene, TOP1mt.

To understand the determinants of response to topoisomerase inhibitors, he is studying the repair pathway centered on tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2) and poly(ADP-ribose)polymerases (PARP).

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Specialties

Biochemistry and Molecular Genetics, Oncology, Precision Oncology medicine

Interested Topics

DNA Topoisomerases in Cancer Chemotherapy, DNA topoisomerases, DNA repair, Cell cycle checkpoints, HIV integrase, Mitochondria

State Licenses

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Professional Association

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Languages

English

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