Yasushi Ishihama PhD

Dr. Yasushi Ishihama is a Professor, Laboratory of Molecular & Cellular BioAnalysis / Laboratory of Proteomics and Drug Discovery Graduate School of Pharmaceutical Sciences at Kyoto University. Yasushi Ishihama worked on micro- or nano-scale separation biosciences using capillary electrophoresis and chromatography as well as mass spectrometry and applied them to drug discovery and development in the pharmaceutical industry.

After moving to Keio University in 2006, he has focused on two main topics such as phosphoproteome and membrane proteome, and developed hydroxy acid-modified metal oxide chromatography (HAMMOC) for phosphopeptide enrichment and phase transfer surfactant (PTS)- aided protease digestion for membrane proteome, respectively. Based on these techniques, his group carried out several phospho- and/or membrane proteomics projects on human cancer, malaria, plants, and bacteria. Recently, his group together with RIKEN Plant Science Center reported the first large-scale plant phosphoproteome analysis including tyrosine phosphorylation (Mol Syst Biol 2008). He is also interested in computational analysis for large-scale proteomics data in collaboration with the Keio SFC bioinformatics group (Mol Cell Proteomics 2009, BMC Bioinformatics 2010 & PLoS Comput Biol 2011).