Wolfgang studied physics at the University of Freiburg, where he obtained a Ph.D. in theoretical physics on stochastic models of open quantum systems. He moved to California in 1998 to do postdoctoral research in cheminformatics of small, drug-like compounds at IBM Research in San Jose, California. In 2000, his interest in cancer genomics and microarray analysis led him to the German Cancer Research Centre (DKFZ) in Heidelberg. In 2004, he joined EMBL to start a research group at the European Bioinformatics Institute (EBI) in Cambridge. In 2009, he took up a position in the newly formed Genome Biology unit of EMBL in Heidelberg, and in 2011 was promoted to EMBL Senior Scientist.
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