Warren Sherman MD

Dr Sherman and his colleagues developed catheter-based techniques for applying biologics to the heart,recently with the goal of identifying mechanisms for increasing efficiency of stem cell retention. These entail assessments that encompass both bench-top and large animal investigations, the latter utilizing models of ischemic injury. Early work with autologous skeletal myoblasts in systolic left ventricular dysfunction has led to the development of clinical trials (Phase I-III) in patients with congestive heart failure. In parallel and in collaboration with other investigators, clinical investigations have expanded to include novel protocols for acute and chronic myocardial injury.