Vadim Fedorov PhD

Dr. Fedorov’s laboratory research is focused on the development of new targeting antiarrhythmic treatments, by using state-of-the-art 3D imaging techniques to uncover functional, structural and molecular mechanisms of malignant cardiac arrhythmias in the human heart. Our main research focus is to understand how tachy-and brady-arrhyhtmias can occur due to congestive heart failure, infarct, and/or aging. One of the goals of our laboratory research is to determine the functional and molecular remodeling, during heart failure and myocardial infarction, of the specialized pacemaker structures and their role in the mechanisms of atrial fibrillation and sinus nodal dysfunction (the leading cause of electronic pacemaker implantation) using animal transgenic models and explanted human hearts. Our research will lead to the development of novel pharmacological, device and genetic/cellular therapeutic defibrillation strategies.