Ulrich H.w. Beuers

Dr.H.W. Beuers is cuurently Professor at University Of amsterdam. His Research interests are Pathogenetic and therapeutic aspects of chronic cholestatic liver diseases. The pathophysiology of chronic cholestatic and autoimmune liver diseases like primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes, IgG4-associated cholangitis and various genetic cholestatic disorders is still only partly understood. Although evidence-based therapies are now available for some of these diseases such as primary biliary cirrhosis and autoimmune hepatitis, many more efforts are needed to disclose the pathophysiological mechanisms leading to these diseases and their progression as well as the symptoms like pruritus and fatique from which the majority of affected patients suffer. Using the full spectrum of laboratory techniques, ranging from basic biochemistry and in vitro cell biology to mouse models and translational studies, we try to gain more insight in the pathophysiology of, and possible novel therapeutic approaches towards cholestatic and autoimmune liver diseases.