Tong-Chuan He completed his medical school education from Chongqing Medical University, Chongqing, China and received his PhD degree in Molecular Cell Biology from the Pennsylvania State University, PA, USA. Upon completing his postdoctoral training at the Howard Hughes Medical Institute and Johns Hopkins Oncology Center, Dr. He was recruited as a faculty and the Director of Molecular Oncology Laboratory at The University of Chicago Medical Center, where he stays since and is now a tenured faculty member. Dr. He identified c-Myc as the first downstream target of the Wnt/b-catenin pathway in colorectal cancer and was the original developer of the And Easy system, which has been used by more than 3,000 academic and pharmaceutical laboratories worldwide. His lab has a broad range of research interests including cancer biology, cell signaling, stem cell biology, cell and gene therapy, and regenerative medicine.