Tatiana Silva PhD

Tatiana Claro da Silva is a Primary Regulatory Reviewer and Regulatory Project Manager at the Division of Vaccines and Related Product Applications (DVRPA), within the Center for Biologics Evaluation and Research (CBER), at the U.S. Food and Drug Administration (FDA).

Prior to this position, she was an ORISE fellow at the FDA, where she applied Physiologically Based Pharmacokinetic (PBPK) modeling to study the role of renal transporters on nephrotoxic drugs and drug-drug interactions. Before joining the FDA, Tatiana worked as a post-doctoral fellow at the University Hospital of Zurich, in Switzerland. The main focus of her work was the regulation of drug and nutrient transporters, especially the zinc and manganese transporter ZnT10 (SLC30A10), as well as Metabolizing Enzymes, by the vitamin D receptor (VDR). She also investigated the epigenetic regulation of the human Organic Anion Transporting Polypeptide 1A2 (hOATP1A2, SLCO1A2) and the human Protein-Coupled Folate Transporter (hPCFT, SLC46A1) by micro RNAs.

Tatiana received her PhD in 2011, from the University of Maryland in Baltimore, USA. During her PhD, she studied the Apical Sodium-dependent Bile Acid Transporter (hASBT, SLC10A2) - a promising prodrug transporter - from the structure-activity and protein stability standpoints. Also during her PhD training, she has produced three papers as second author and two first-author papers.

In 2007, she received the Pharmaceutical Sciences Teaching Scholarship Award and in 2009 the Pharmaceutical Sciences Merit Award, both from the University of Maryland in Baltimore. Also in 2007, she was elected president of the Pharmaceutical Sciences Graduate Students Association (PGA). Tatiana is a member of the Phi Kappa Phi and the Rho Chi Pharmacy Honor Societies.