Speaker Profile
Steven W. Millward

Steven W. Millward PhD

Healthcare Management
Houston, Texas, United States of America

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Dr. Steven Millward’s group is working at the chemistry-biology interface to develop new molecular imaging agents to visualize the hallmarks of cancer in living systems. His laboratory is using directed evolution, chemical biology, and metabolomics to design novel compounds that can be directly integrated into optical, nuclear, and MR-based imaging platforms. Directed Evolution of Imaging Agents. The ideal molecular imaging agent would have the affinity and target specificity of monoclonal antibodies along with the rapid systemic clearance of small molecules. While peptides have shown promise as in vitro imaging probes, their short half-life, poor stability, and low affinity have traditionally made them unsuitable for in vivo applications. They are using mRNA display in conjunction with chemical modification to select for high-affinity, modification-resistant peptides in ex vivo and in vivo systems.
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