Steven S. Gross BS, PhD, MPH

Steven major research interest over the past two decades has been elucidating mechanisms of cell signaling by reactive molecules, with a primary focus on the physiological chemistry and biology of nitric oxide (NO). Work on NO has culminated in over 25 issued US patents and co-founding of a biotech start-up that conducted a multinational phase III clinical study to test the therapeutic efficacy of a NOS inhibitor for a life-saving cardiovascular indication. Since reactive molecules typically mediate their cell signaling actions by engaging in covalent reactions with proteins, he worked to develop proteomic approaches that can be used to define and inventory various NO-mediated protein modifications. These efforts led to an interest inbiological mass spectrometry (MS) and his establishment in 1997 of the MS core facility at Weill Cornell Medical College. As Director of the MS core facility, he acquired experience and know-how in the use of bioanalytical techniques for high-throughput protein and small molecule analyses.