Sophia Hober PhD

Sophia Hober is a Professor of Molecular Biotechnology at KTH, Stockholm, Sweden. She is part of the executive management team of the Human Protein Atlas and the Secretome project. Also, from 2011 to 2015 she was dean of faculty at KTH and thereby also part of the executive management team at KTH. She has published more than 115 scientific papers.

The focus of her current research group is the development of predictable and robust systems for protein purification and detection through protein design and various selection methodologies. Her key scientific achievements include the characterization of the folding pathway of IGF‑1, and the design, and development of gene fusion systems for selective ion‑exchange purification. Furthermore, she has developed a novel protein domain with calcium-dependent affinity and improved the alkaline tolerance of protein A and protein G for industrial purification of IgG/HSA (currently a product sold by GE Healthcare). Moreover, small bispecific protein domains with the ability to strongly and selectively bind to two different proteins have been developed. These domains have been designed for use in protein purification as well as for cancer theranostics.