Shane Needham BS, PhD

Dr. Shane Needham received his B.S. degree in chemistry from Washington State University and his Ph.D. in chemistry from the University of Rhode Island. Dr. Needham is Co-Founder and Laboratory Director of Alturas Analytics, Inc. Dr. Needham manages all scientific aspects of the LC-MS/MS bioanalytical contract laboratory at Alturas Analytics, Inc. Currently, Dr. Needham’s work is focused on the development and validation of assays for the determination of therapeutic agents and biomarkers from biological matrices. His laboratory has been a leader in the area of dried blood spot (DBS) analysis, microflow LC-MS/MS and GC-MS/MS to support DMPK research.

Dr. Needham has over 100 publications and external presentations in the area of LC/MS. He has over 25 years of LC/MS and analytical lab experience in the drug discovery through drug development stage in the pharmaceutical industry. He previously worked for Pfizer in Groton, CT where he developed and validated GLP and non-GLP LC-MS/MS methods for the trace analysis of drugs and metabolites in biological fluids. He also performed in vivo and in vitro structure elucidation studies of drugs and metabolites using HPLC/MS/MS and HPLC/MSn instrumentation. Dr. Needham has LC/MS experience working with triple quadrupole, single quadrupole, ion trap, time-of-flight and quadrupole time-of-flight instrumentation. His area of academic research included the development of optimized stationary phases to improve the assay of pharmaceuticals by HPLC/MS.

Dr. Needham has been the chair and organizer of several workshops at national conferences including program chair of the 2013 CPSA-USA conference. Dr. Needham also teaches LC/MS courses at international conferences including, CPSA, Pittcon and AAPS conferences. Dr. Needham is also a reviewer for several peer reviewed journals including, Bioanalysis, Journal of Chromatography, Analytical Chemistry and Journal of Chromatographic Science. Dr. Needham also serves on the editorial board for the publication, American Pharmaceutical Review. Dr. Needham is a member of the American Chemical Society, American Society for Mass Spectrometry, American Association of Pharmaceutical Scientists and the International Society of the Study of Xenobiotics.