Shailesh is Associate Principle Scientist in Discovery Sciences iMED, AstraZeneca based in Sweden. Shailesh has been using CRISPR/Cas9 and human iPS cells to generate cellular models to understand disease biology and drive drug discovery projects in cardiovascular, metabolic & CNS diseases. Before joining AstraZeneca Shailesh was in Singapore, working for GlaxoSmithKline (GSK), in a group that was focused on modeling CNS diseases & developing novel assays using Stem Cells & iPSCs.
Shailesh has a strong background in genome editing, cell based high content small molecule screening, assay development and human stem cells/iPSCs based disease modeling. Previous to his position at GSK, Shailesh was postdoc at Harvard University performing research focused on developing novel therapeutics for ALS disease through high content small molecule screen using motor neurons derived from embryonic stem cells. Shailesh has a PhD in developmental neuroscience
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