Sebastian Kohler PhD

Dr Köhler has published articles in the field of disease gene prioritization by using complex networks and machine learning methods. He has been working on development and validation of computational methods for network- and ontology-based research on genotype- to-phenotype relations. He is one of the founders and major developers of the Human Phenotype Ontology (HPO) and related cross-species phenotype resources. He has developed software that uses the HPO to perform phenotype-driven analysis of genomic variation, such as single nucleotide variations or Copy-number variations.