Sarosh R. Irani FRCP, DPhil, FEAN

Sarosh Irani is a clinician-scientist who leads the Oxford Autoimmune Neurology Group to better manage and study autoantibody-mediated diseases of the nervous system. Dr. Irani undertook clinical training in Oxford and London, with a DPhil in Oxford and a Fulbright postdoctoral position at UCSF. He has made several clinical discoveries including the recognition of faciobrachial dystonic seizures and other distinctive psychopathological features associated with NMDAR-antibody encephalitis. In the laboratory, he has led the discovery of LGI1- and CASPR2-antibodies, their associated HLA associations, and the roles of B cells in the pathogenesis of autoimmune forms of encephalitis and neuromyelitis optica. He was awarded the Graham-Bull Prize in Clinical Science / Goulstonian Lectureship, from the Royal College of Physicians, and awards including the NIHR BRC Senior Clinical Fellowship and both Wellcome Intermediate and MRC Senior Clinical Fellowships. He runs the UK’s major clinic for antibody-mediated CNS diseases and continues to explore the immunobiology and neuroscience which underlie autoimmune neurological diseases.

Dr. Irani is a consultant neurologist and clinician-scientist with clinical and laboratory experiences in the field of autoantibody-mediated diseases of the nervous system, in particular the central nervous system. He runs a dedicated clinic for the care of these patients, with a neuropsychiatrist and an encephalitis nurse. In parallel, Dr. Irani runs a research group of clinicians and scientists to learn more about the origins and treatments of these diseases. More than 95% of his patients participate in research projects, from which they make direct and key contributions to the progress of the field.