Sacha S. Zeerleder MD, PhD

Professor Sacha Zeerleder is an Internist-Hematologist at the Academic Medical Center and senior staff member at the department of immunopathology at Sanquin Research in Amsterdam (The Netherlands). He is the director of the hematopoietic stem cell transplantation program and medical head of the special hematology and transfusion laboratory of the Academic Medical Center.

Zeerleder’s research is dedicated to the role of the innate immunity in hematological diseases. This mainly includes studies on mechanisms on how damage-associated molecular patterns (DAMPs) are released, the regulation hereof and how DAMPs induce systemic inflammation with a special interest in the role of plasma proteins (complement, coagulation) and plasma inhibitors herein. To study these concepts a main focus lies on diseases of systemic inflammation induced by infection (e.g. (neutropenic) sepsis), graft-vs-host disease or intravascular hemolysis such as autoimmune hemolytic anemia (AIHA), paroxysmal hemoglobinuria (PNH) and sickle cell disease.