Ruli Gao PhD

Dr. Gao and colleagues developed the punctuated copy number evolution model in primary triple-negative breast cancer challenging the Darwinian Gradualism. she proposed a bi-mode chemoresistance evolution model where an adaptive selection of genotypes and inductive reprogramming of phenotypes are activated in parallel in triple-negative breast cancer patients. She also developed a nano grid single nuclear RNA sequencing method that opened the avenue of analyzing single-cell transcriptomes from archival frozen tissue samples. Moving forward, her research is focusing on developing novel computational tools to integrate single-cell multi-omics and establishing new experimental pipelines to perform the third generation of a single-cell long read and spatial sequencing to unveil both somatic and mosaic genetic abnormalities that underly human cancers, neurodegenerative disorders, and heart diseases.