Ronald D. Perrone MD

Dr. Perrone is the Director of the Polycystic Kidney Disease Center at Tufts Medical Center. His present work focuses on clinical research in polycystic kidney disease and the role of total kidney volume as a biomarker in response to clinical therapies. Dr. Perrone was a member of the Scientific Advisory Committee of the Polycystic Kidney Disease Foundation from 1999 to 2016 (Chairman from 2006-2010) and frequently lectures at national and local patient meetings.

Dr. Perrone has had a major role in global and national clinical trials for ADPKD. He served as site PI and member of the steering committee for the TEMPO 251 and REPRISE studies of tolvaptan in ADPKD. Dr. Perrone was site PI and a member of the steering committee for the NIDDK-sponsored HALT PKD study.

Dr. Perrone and colleagues at the University of Maryland, Baltimore, and the University of Pittsburgh received a 5-year grant from the Department of Defense to study metformin as a clinical intervention in ADPKD (TAME PKD). This trial has completed its recruitment goals and will report results in 2021. Dr. Perrone is co-Principal Investigator and co-chair of the steering committee for the Sanofi PKD trial of venglustat (STAGED-PKD), site PI of the Kadmon PKD trial of tesevatinib, and site PI of the Reata PKD trial of bardoxolone (Falcon).

Over the past 10 years, Dr. Perrone has been integral to the formation of the PKD Outcomes Consortium and has been the principal individual involved in bringing together the contributors from academia, pharma, NIH, FDA, CDISC, and C-Path. He has led this large and diverse consortium that is creating the groundwork for the validation of total kidney volume as a clinical trial and regulatory endpoint in ADPKD. Dr. Perrone’s goal, enhanced by prior experience in epithelial biology, clinical trials, dietary modification, and translation of basic discoveries to clinical care, is to improve outcomes in chronic kidney disease, particularly polycystic kidney disease.

Dr. Perrone is the Scientific Director of the Clinical and Translational Research Center (CTRC), under the auspices of the Tufts Clinical and Translational Science Institute. The CTRC is the main site for clinical research studies at Tufts Medical Center. His role is to provide scientific leadership and facilitate research activities in the CTRC.