Robert C. Huebert MD

The research program of Robert C. Huebert, M.D., focuses broadly on liver regenerative medicine, with a focus on understanding and treating the cholangiopathies, a diverse group of diseases targeting the biliary tree. Dr. Huebert's laboratory seeks to understand the molecular mechanisms that drive biliary development, regeneration and repair, including the signaling pathways and epigenetic events that drive these processes.

In addition, the laboratory has developed a novel method for the derivation of the epithelial cells that line the bile ducts (cholangiocytes) from induced pluripotent stem cells (iPSCs). The lab is using this method to populate the Liver Biobank, a biorepository of iPSCs from patients with liver disease. The biobank will be used for individualized disease modeling, pharmacological testing and developing cell-therapy applications.